Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study.
Camille Amadieu, Quentin Leyrolle, Milena Farneti, Andrea Anesi, Eva Bruchet, Juliette Montet, Sandra Dexpert, David Gaudout, Fulvio Mattivi, Line Pourtau, Nathalie Castanon, Lucile Capuron
The American Journal of Clinical Nutrition. 2025-12-01
10.1016/j.ajcnut.2025.09.050

Obesity-induced emotional alterations in mice are associated with impairments of tryptophan metabolism along the kynurenine and indole pathways
Nathalie Castanon, Sylvie Vancassel, Camille Amadieu, Sofia Cussotto, Quentin Leyrolle, Céline Lucas, Antoine Lefevre, Patrick Emond, Anne-Laure Dinel, Lucile Capuron
Brain, Behavior, and Immunity. 2025-11-01
10.1016/j.bbi.2025.106107

Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
Audrey M. Neyrinck, Hany Ahmed, Quentin Leyrolle, Sophie Leclercq, Camille Amadieu, Topi Meuronen, Sophie Layé, Patrice D. Cani, Olli Kärkkäinen, Laure B. Bindels, Kati Hanhineva, Nathalie M. Delzenne
Sci Rep. 2025-05-02
10.1038/s41598-025-99047-z

Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Camille Amadieu, Hany Ahmed, Sophie Leclercq, Ville Koistinen, Quentin Leyrolle, Peter Stärkel, Laure B. Bindels, Sophie Layé, Audrey M. Neyrinck, Olli Kärkkäinen, Philippe De Timary, Kati Hanhineva, Nathalie M. Delzenne
Clinical Nutrition ESPEN. 2025-04-01
10.1016/j.clnesp.2025.01.046

Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Sophie Leclercq, Hany Ahmed, Camille Amadieu, Géraldine Petit, Ville Koistinen, Quentin Leyrolle, Marie Poncin, Peter Stärkel, Eloise Kok, Pekka J Karhunen, Philippe de Timary, Sophie Laye, Audrey M Neyrinck, Olli K Kärkkäinen, Kati Hanhineva, Nathalie Delzenne
eLife. 2024-11-29
10.7554/eLife.96937

Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging
Camille Mougin, Mathilde Chataigner, Céline Lucas, Quentin Leyrolle, Véronique Pallet, Sophie Layé, Elodie Bouvret, Anne-Laure Dinel, Corinne Joffre
Foods. 2023-11-21
10.3390/foods12234199

The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain.
Quentin Leyrolle, Lucia Prado-Perez, Sophie Layé
Front. Nutr.. 2023-06-09
10.3389/fnut.2023.1155533

Microbiota-derived metabolites as drivers of gut-brain communication.
Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Kärkkäinen, Sophie Layé, Nathalie Delzenne, Kati Hanhineva
Gut Microbes. 2022-07-28
10.1080/19490976.2022.2102878

Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
Quentin Leyrolle, Renata Cserjesi, Romane Demeure, Audrey M. Neyrinck, Camille Amadieu, Julie Rodriguez, Olli Kärkkäinen, Kati Hanhineva, Nicolas Paquot, Miriam Cnop, Patrice D. Cani, Jean-Paul Thissen, Laure B. Bindels, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne
Nutrients. 2021-12-29
10.3390/nu14010147

Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients
Camille Amadieu, Valentin Coste, Audrey M. Neyrinck, Victoria Thijssen, Quentin Leyrolle, Laure B. Bindels, Hubert Piessevaux, Peter Stärkel, Philippe de Timary, Nathalie M. Delzenne, Sophie Leclercq
Gut Microbes. 2021-12-20
10.1080/19490976.2021.2007042

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar
Cannabis and Cannabinoid Research. 2021-12-01
10.1089/can.2020.0170

N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar
Glia. 2021-09-14
10.1002/glia.24088

Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial
Quentin Leyrolle, Renata Cserjesi, Maria D.G.H. Mulders, Giorgia Zamariola, Sophie Hiel, Marco A. Gianfrancesco, Daphné Portheault, Camille Amadieu, Laure B. Bindels, Sophie Leclercq, Julie Rodriguez, Audrey M. Neyrinck, Patrice D. Cani, Nicolas Lanthier, Pierre Trefois, Jérome Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne
Brain, Behavior, and Immunity. 2021-05-01
10.1016/j.bbi.2021.01.014

Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients
Quentin Leyrolle, Renata Cserjesi, Maria D.G.H. Mulders, Giorgia Zamariola, Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Camille Amadieu, Sophie Leclercq, Laure B. Bindels, Audrey M. Neyrinck, Patrice D. Cani, Olli Karkkainen, Kati Hanhineva, Nicolas Lanthier, Pierre Trefois, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne
Clinical Nutrition. 2021-04-01
10.1016/j.clnu.2020.09.025

Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice
Christelle Knudsen, Audrey M Neyrinck, Quentin Leyrolle, Pamela Baldin, Sophie Leclercq, Julie Rodriguez, Martin Beaumont, Patrice D Cani, Laure B Bindels, Nicolas Lanthier, Nathalie M Delzenne
The Journal of Nutrition. 2021-03-10
10.1093/jn/nxab032

Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial
Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Quentin Leyrolle, Laure B. Bindels, Carolina Gomes da Silveira Cauduro, Maria D.G.H. Mulders, Giorgia Zamariola, Anne-Sophie Azzi, Gaetan Kalala, Barbara D. Pachikian, Camille Amadieu, Audrey M. Neyrinck, Audrey Loumaye, Patrice D. Cani, Nicolas Lanthier, Pierre Trefois, Olivier Klein, Olivier Luminet, Jérôme Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Nathalie M. Delzenne
Clinical Nutrition. 2020-12-01
10.1016/j.clnu.2020.04.005

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Nat Commun. 2020-11-30
10.1038/s41467-020-19861-z

Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder
Sophie Leclercq, Tiphaine Le Roy, Sonia Furgiuele, Valentin Coste, Laure B. Bindels, Quentin Leyrolle, Audrey M. Neyrinck, Caroline Quoilin, Camille Amadieu, Géraldine Petit, Laurence Dricot, Vanessa Tagliatti, Patrice D. Cani, Kristin Verbeke, Jean-Marie Colet, Peter Stärkel, Philippe de Timary, Nathalie M. Delzenne
Cell Reports. 2020-10-01
10.1016/j.celrep.2020.108238

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar
Neuropsychopharmacol.. 2020-08-11
10.1038/s41386-020-00793-7

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients
Julie Rodriguez, Sophie Hiel, Audrey M Neyrinck, Tiphaine Le Roy, Sarah A Pötgens, Quentin Leyrolle, Barbara D Pachikian, Marco A Gianfrancesco, Patrice D Cani, Nicolas Paquot, Miriam Cnop, Nicolas Lanthier, Jean-Paul Thissen, Laure B Bindels, Nathalie M Delzenne
Gut. 2020-02-10
10.1136/gutjnl-2019-319726

Food4Gut multicenter randomized placebo-controlled trial. v1
Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Quentin Leyrolle, Laure B. Bindels, Carolina Gomes da Silveira Cauduro, Maria D.G.H. Mulders, Giorgia Zamariola, Anne-Sophie Azzi, Gaetan Kalala, Barbara D. Pachikian, Camille Amadieu, Audrey M. Neyrinck, Audrey Loumaye, Patrice D. Cani, Nicolas Lanthier, Pierre Trefois, Olivier Klein, Olivier Luminet, Jérôme Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Nathalie M. Delzenne
. 2019-12-16
10.17504/protocols.io.baidica6

SUN-PO285: Implication of the Gut Microbiota in Personalized Metabolic Response to Dietary Inulin in Obese Patients
J. Rodriguez, A. Neyrinck, T. Le roy, S. Hiel, Q. Leyrolle, L. Bindels, P. Cani, M. Cnop, N. Paquot, N. Lanthier, J.P. Thissen, N. Delzenne
Clinical Nutrition. 2019-09-01
10.1016/s0261-5614(19)32915-2

Direct and indirect effects of lipids on microglia function
Q. Leyrolle, S. Layé, A. Nadjar
Neuroscience Letters. 2019-08-01
10.1016/j.neulet.2019.134348

Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2019-05-01
10.1016/j.bbi.2019.05.016

Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé
Brain, Behavior, and Immunity. 2018-10-01
10.1016/j.bbi.2018.06.004

Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Agnes Nadjar, Quentin Leyrolle, Corinne Joffre, Sophie Layé
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases.
10.1016/b978-0-12-811959-4.00024-9

Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01
10.1016/j.pnpbp.2016.07.004

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol.
10.1371/journal.pbio.1002554

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLOS Biology. 2016-06-30
10.1371/journal.pbio.1002508

Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra
PLoS Biol. 2016-05-26
10.1371/journal.pbio.1002466

N-3 PUFAs and neuroinflammatory processes in cognitive disorders
Quentin Leyrolle, Sophie Layé, Agnès Nadjar
OCL. 2016-01-01
10.1051/ocl/2015064

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé
Neural Plasticity. 2016-01-01
10.1155/2016/3597209