Vitamin A deficiency induces sex-specific reward processing alterations through a dysregulation of the mesolimbic dopamine transmission in mice.
Pauline Couty, Sonya Yung, Ilona Dulapt, Loreleï Berger, Adrien Santoro, Lola Hardt, Anna Petitbon, Fabien Ducrocq, Roman Walle, Julien Catanese, Serge Alfos, Jean-Christophe Helbling, Maria-Florencia Angelo, Charlotte Sabran, Patrick Borel, Guillaume Ferreira, Clémentine Bosch-Bouju, Pierre Trifilieff, Katia Touyarot
Neuropsychopharmacol.. 2026-04-04
10.1038/s41386-026-02400-7

The sodium leak channel NALCN in Drd2+ striatal neurons regulates neuronal excitability, locomotion and food-seeking in a sex-dependent manner
Laia Castell, Claire Naon, Angelina Rogliardo, Fabien Ducrocq, Leila Makrini, Alexandra Typou, Maëlle Avrillon, Audrey Mignon, Claire Bernat, Philippe Lory, Federica Bertaso, Arnaud Monteil, Clémentine Bosch-Bouju, Emmanuel Valjent
Neuropsychopharmacology. 2026-02-11
10.1038/s41386-026-02363-9

Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice
Fabien Ducrocq, Lianne Delwel, Nick Papavoine, Eileen Brouwer, Karlijn L. Kooij, Inge G. Wolterink-Donselaar, Lisa Drost, Jaimie Hak, Melissa Veendijk, Mieneke C. M. Luijendijk, Frank J. Meye, Roger A. H. Adan
Nat Commun. 2025-12-24
10.1038/s41467-025-67897-w

Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure
Roman Walle, Anna Petitbon, Giulia R. Fois, Christophe Varin, Enrica Montalban, Lola Hardt, Andrea Contini, Maria Florencia Angelo, Mylène Potier, Rodrigue Ortole, Asma Oummadi, Véronique De Smedt-Peyrusse, Roger A. Adan, Bruno Giros, Francis Chaouloff, Guillaume Ferreira, Alban de Kerchove d’Exaerde, Fabien Ducrocq, François Georges, Pierre Trifilieff
Nat Commun. 2024-03-21
10.1038/s41467-024-46874-9

GLP-1 receptor agonist semaglutide reduces appetite while increasing dopamine reward signaling
Karlijn L. Kooij, Derek IJsbrand Koster, Emma Eeltink, Mieneke Luijendijk, Lisa Drost, Fabien Ducrocq, Roger A.H. Adan
Neuroscience Applied. 2024-01-01
10.1016/j.nsa.2023.103925

Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.
Marie-Lise Jobin, Véronique De Smedt-Peyrusse, Fabien Ducrocq, Rim Baccouch, Asma Oummadi, Maria Hauge Pedersen, Brian Medel-Lacruz, Maria-Florencia Angelo, Sandrine Villette, Pierre Van Delft, Laetitia Fouillen, Sébastien Mongrand, Jana Selent, Tarson Tolentino-Cortez, Gabriel Barreda-Gómez, Stéphane Grégoire, Elodie Masson, Thierry Durroux, Jonathan A. Javitch, Ramon Guixà-González, Isabel D. Alves, Pierre Trifilieff
Mol Psychiatry. 2023-01-06
10.1038/s41380-022-01928-6

Motivational deficits and polyunsaturated fatty acids
Fabien Ducrocq, Pierre Trifilieff
Med Sci (Paris). 2021-01-01
10.1051/medsci/2020250

Type 2 DiabetesAssociated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons
HUGO MARTIN, SÉBASTIEN BULLICH, FABIEN DUCROCQ, MARION GRALAND, CLARA OLIVRY, SOPHIE LAYE, BRUNO GUIARD, XAVIER FIORAMONTI
Diabetes. 2020-06-01
10.2337/db20-1758-p

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.
Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, Suzanne van der Veldt, Marie-Lou Boyer, Frank Aby, Tarson Tolentino-Cortez, Jean-Christophe Helbling, Lucy Martine, Stéphane Grégoire, Stéphanie Cabaret, Sylvie Vancassel, Sophie Layé, Jing Xuan Kang, Xavier Fioramonti, Olivier Berdeaux, Gabriel Barreda-Gómez, Elodie Masson, Guillaume Ferreira, David W.L. Ma, Clementine Bosch-Bouju, Véronique De Smedt-Peyrusse, Pierre Trifilieff
Cell Metabolism. 2020-04-01
10.1016/j.cmet.2020.02.012

Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice
H. Fanet, F. Ducrocq, M. Tournissac, A. Oummadi, A. Lo, P. Bourrassa, V. De Smedt-Peyrusse, B. Azzougen, L. Capuron, S. Layé, F. Moussa, P. Trifilieff, F. Calon, S. Vancassel
Behavioural Brain Research. 2020-02-01
10.1016/j.bbr.2019.112348

Microarray and Mass Spectrometry-Based Methodology for Lipid Profiling of Tissues and Cell Cultures
Roberto Fernández, Jone Garate, Tarson Tolentino-Cortez, Ainara Herraiz, Laura Lombardero, Fabien Ducrocq, Rafael Rodríguez-Puertas, Pierre Trifilieff, Egoitz Astigarraga, Gabriel Barreda-Gómez, José A. Fernández
Anal. Chem.. 2019-11-21
10.1021/acs.analchem.9b04529

Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A. Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C. Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard
J. Neurosci.. 2019-06-03
10.1523/jneurosci.2904-18.2019

Decrease in Operant Responding Under Obesogenic Diet Exposure is not Related to Deficits in Incentive or Hedonic Processes.
Fabien Ducrocq, Alexia Hyde, Hortense Fanet, Asma Oummadi, Roman Walle, Véronique De Smedt-Peyrusse, Sophie Layé, Guillaume Ferreira, Pierre Trifilieff, Sylvie Vancassel
Obesity. 2018-12-30
10.1002/oby.22358

Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior.
Pierre Trifilieff, Fabien Ducrocq, Suzanne van der Veldt, Diana Martinez
Seminars in Nuclear Medicine. 2017-01-01
10.1053/j.semnuclmed.2016.09.003