Balanced polyunsaturated fatty acids diet prevents the D-galactose-induced neuroinflammation and cognitive impairments
Ivan Marniquet, Juliette Dupont-Viratelle, Flavie Crespo, Alexandra Séré, Sophie Layé, Jean-Christophe Delpech
Neuroscience Applied. 2026-01-01
10.1016/j.nsa.2026.106989

Technical note: Efficient enrichment of plasma-derived extracellular vesicles from small volumes of bovine blood
Vincent Prieur, Cassar-Malek Isabelle, Delavaud Arnaud, Barry-Carroll Liam, Delpech Jean-Christophe, Morel Isabelle, Lerch Sylvain, Viala Didier, Chennell Philip, Boby Céline, Bonnet Muriel
Journal of Animal Science. 2025-10-15
10.1093/jas/skaf354

Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research
Pasindu Hansana Singhaarachchi, Peter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Aniko Korosi, Sophie Layé, Jonathan McQualter, Susanne R. de Rooij, Christoph Rummel, Mary Slayo, Luba Sominsky, Sarah J. Spencer
Progress in Neurobiology. 2025-09-01
10.1016/j.pneurobio.2025.102821

GLP-1-mediated targeting of inflammation corrects obesogenic memory in male mice
Stéphane Léon, Julie Benoit, Samantha Clark, Philippe Zizzari, Bin Yang, Isabelle Dugail, Fatiha Merabtene, Karine Clement, Louise Eygret, Nathalie Dupuy, Jean-Christophe Delpech, Moïra Rossitto, Matthias Mack, Thierry Lesté-Lasserre, Brian Finan, Daniela Cota, Carmelo Quarta
Diabetes. 2025-04-11
10.2337/db24-1071

Efficient enrichment of plasma-derived extracellular vesicles from small volumes of bovine blood
Vincent Prieur, Cassar-Malek Isabelle, Delavaud Arnaud, Barry-Carroll Liam, Delpech Jean-Christophe, Morel Isabelle, Lerch Sylvain, Viala Didier, Chennell Philip, Boby Céline, Bonnet Muriel
Journal of Animal Science. 2025-01-01
10.1093/jas/skaf354

Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.
Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé
Sci Rep. 2024-11-30
10.1038/s41598-024-80770-y

Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer's disease research.
Pasindu Hansana Singhaarachchi, Peter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Aniko Korosi, Sophie Layé, Jonathan McQualter, Susanne R. de Rooij, Christoph Rummel, Mary Slayo, Luba Sominsky, Sarah J. Spencer
Neuroscience & Biobehavioral Reviews. 2024-07-01
10.1016/j.neubiorev.2024.105724

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
Zhuoran Yin, Shawn Herron, Sebastian Silveira, Kilian Kleemann, Christian Gauthier, Dania Mallah, Yiran Cheng, Milica A. Margeta, Kristen M. Pitts, Jen-Li Barry, Ayshwarya Subramanian, Hannah Shorey, Wesley Brandao, Ana Durao, Jean-Christophe Delpech, Charlotte Madore, Mark Jedrychowski, Amrendra K. Ajay, Gopal Murugaiyan, Samuel W. Hersh, Seiko Ikezu, Tsuneya Ikezu, Oleg Butovsky
Nat Neurosci. 2023-06-08
10.1038/s41593-023-01355-y

Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity
Shawn Herron, Jean-Christophe Delpech, Charlotte Madore, Tsuneya Ikezu
STAR Protocols. 2022-12-01
10.1016/j.xpro.2022.101670

Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
Diankun Yu, Tao Li, Jean-Christophe Delpech, Beika Zhu, Priya Kishore, Tatsuhiro Koshi, Rong Luo, Karishma J.B. Pratt, Galina Popova, Tomasz J. Nowakowski, Saul A. Villeda, Xianhua Piao
Sci. Adv.. 2022-05-06
10.1126/sciadv.abm2545

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar
Front. Cell. Neurosci.. 2022-02-10
10.3389/fncel.2022.802411

Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu
Sci. Transl. Med.. 2021-09-15
10.1126/scitranslmed.abe8455

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu
Mol Neurodegeneration. 2021-04-14
10.1186/s13024-021-00447-2

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu
Mol Neurodegeneration. 2021-03-22
10.1186/s13024-021-00440-9

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Nat Commun. 2020-11-30
10.1038/s41467-020-19861-z

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu
Mol Neurodegeneration. 2020-08-18
10.1186/s13024-020-00396-2

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, Maya E. Woodbury, Alicia A. Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B. Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W. Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu
Mol Psychiatry. 2020-02-18
10.1038/s41380-020-0671-2

Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.
Yang You, Mina B. Botros, Alicia A. Van Enoo, Aaron Bockmiller, Shawn Herron, Jean Christophe Delpech, Tsuneya Ikezu
Neuroscience. 2019-12-01
10.1016/j.neuroscience.2019.10.001

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
Jean-Christophe Delpech, Shawn Herron, Mina B. Botros, Tsuneya Ikezu
Trends in Neurosciences. 2019-05-01
10.1016/j.tins.2019.02.007

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2019-02-01
10.1016/j.bbi.2018.07.025

Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.
Ernest M. Graham, Allen D. Everett, Jean-Christophe Delpech, Frances J. Northington
Current Opinion in Pediatrics. 2018-04-01
10.1097/mop.0000000000000591

Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.
Frances K. Johnson, Jean-Christophe Delpech, Garth J. Thompson, Lan Wei, Jin Hao, Peter Herman, Fahmeed Hyder, Arie Kaffman
Transl Psychiatry. 2018-02-21
10.1038/s41398-018-0092-z

Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.
Eric S. Wohleb, Jean-Christophe Delpech
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01
10.1016/j.pnpbp.2016.04.013

Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production.
Frédéric Villéga, Jean-Christophe Delpech, Marion Griton, Caroline André, Jean-Michel Franconi, Sylvain Miraux, Jan Pieter Konsman
Neuroscience. 2017-03-01
10.1016/j.neuroscience.2017.01.018

Early life stress perturbs the maturation of microglia in the developing hippocampus.
Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffman
Brain, Behavior, and Immunity. 2016-10-01
10.1016/j.bbi.2016.06.006

Microglia in neuronal plasticity: Influence of stress
Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé
Neuropharmacology. 2015-09-01
10.1016/j.neuropharm.2014.12.034

Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agnès Aubert, Corinne Joffre, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2015-05-07
10.1038/npp.2015.127

Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar
Journal of Neuroscience. 2015-02-18
10.1523/jneurosci.3028-14.2015

Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
Charlotte Madore, Agnès Nadjar, Jean-Christophe Delpech, A. Sere, A. Aubert, Céline Portal, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2014-10-01
10.1016/j.bbi.2014.03.021

Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2014-08-05
10.1038/npp.2014.196

Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging
Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar
PLoS ONE. 2014-02-05
10.1371/journal.pone.0087421

Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide
C. Madore, C. Joffre, J.C. Delpech, V. De Smedt-Peyrusse, A. Aubert, L. Coste, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2013-11-01
10.1016/j.bbi.2013.08.008

Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice
Aurélie Moranis, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Agnès Aubert, Philippe Guesnet, Monique Lavialle, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2012-07-01
10.1016/j.bbi.2011.11.001