Fructose malabsorption induces dysbiosis and increases anxiety in male human and animal models
Adeline Coursan, Delphine Polve, Anne-Marie Leroi, Magali Monnoye, Lea Roussin, Clara Benatar, Marie-Pierre Tavolacci, Muriel Quillard Muraine, Mathilde Maccarone, Olivia Guérin, Estelle Houivet, Charlène Guérin, Valery Brunel, Jérôme Bellenger, Jean-Paul Pais de Barros, Guillaume Gourcerol, Laurent Naudon, Sophie Layé, Charlotte Madore, Xavier Fioramonti, Chloé Melchior, Véronique Douard
Brain, Behavior, and Immunity. 2025-12-01
10.1016/j.bbi.2025.106221

Preventing effect of plant extracts and omega-3 on age-related cognitive decline in male mice
Marie Martin, Adrien Peltier, Heena Vanmalibhai Lad, Aline Foury, Charlotte Madore-Delpech, Line Pourtau, David Gaudout, Sophie Layé, Véronique Pallet, Anne-Laure Dinel, Corinne Joffre
Brain, Behavior, & Immunity - Health. 2025-11-01
10.1016/j.bbih.2025.101127

Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides.
Josephine Louise Robb, Frédérick Boisjoly, Arturo Israel Machuca-Parra, Adeline Coursan, Romane Manceau, Danie Majeur, Demetra Rodaros, Khalil Bouyakdan, Karine Greffard, Jean-François Bilodeau, Anik Forest, Caroline Daneault, Matthieu Ruiz, Cyril Laurent, Nathalie Arbour, Sophie Layé, Xavier Fioramonti, Charlotte Madore, Stephanie Fulton, Thierry Alquier
Brain, Behavior, and Immunity. 2025-01-01
10.1016/j.bbi.2024.09.027

Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.
Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé
Sci Rep. 2024-11-30
10.1038/s41598-024-80770-y

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Zhuoran Yin, Neta Rosenzweig, Kilian L. Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A. Margeta, Caitlin Schroeder, Kisha N. Sivanathan, Sebastian Silveira, Christian Gauthier, Dania Mallah, Kristen M. Pitts, Ana Durao, Shawn Herron, Hannah Shorey, Yiran Cheng, Jen-Li Barry, Rajesh K. Krishnan, Sam Wakelin, Jared Rhee, Anthony Yung, Michael Aronchik, Chao Wang, Nimansha Jain, Xin Bao, Emma Gerrits, Nieske Brouwer, Amy Deik, Daniel G. Tenen, Tsuneya Ikezu, Nicolas G. Santander, Gabriel L. McKinsey, Caroline Baufeld, Dean Sheppard, Susanne Krasemann, Roni Nowarski, Bart J. L. Eggen, Clary Clish, Rudolph E. Tanzi, Charlotte Madore, Thomas D. Arnold, David M. Holtzman, Oleg Butovsky
Nat Immunol. 2023-09-25
10.1038/s41590-023-01627-6

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder
Dilansu Guneykaya, Bilge Ugursu, Francesca Logiacco, Oliver Popp, Maria Almut Feiks, Niklas Meyer, Stefan Wendt, Marcus Semtner, Fatma Cherif, Christian Gauthier, Charlotte Madore, Zhuoran Yin, Özcan Çınar, Taner Arslan, Zoltan Gerevich, Philipp Mertins, Oleg Butovsky, Helmut Kettenmann, Susanne A. Wolf
Brain, Behavior, and Immunity. 2023-07-01
10.1016/j.bbi.2023.03.023

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
Zhuoran Yin, Shawn Herron, Sebastian Silveira, Kilian Kleemann, Christian Gauthier, Dania Mallah, Yiran Cheng, Milica A. Margeta, Kristen M. Pitts, Jen-Li Barry, Ayshwarya Subramanian, Hannah Shorey, Wesley Brandao, Ana Durao, Jean-Christophe Delpech, Charlotte Madore, Mark Jedrychowski, Amrendra K. Ajay, Gopal Murugaiyan, Samuel W. Hersh, Seiko Ikezu, Tsuneya Ikezu, Oleg Butovsky
Nat Neurosci. 2023-06-08
10.1038/s41593-023-01355-y

Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity
Shawn Herron, Jean-Christophe Delpech, Charlotte Madore, Tsuneya Ikezu
STAR Protocols. 2022-12-01
10.1016/j.xpro.2022.101670

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
Milica A. Margeta, Zhuoran Yin, Charlotte Madore, Kristen M. Pitts, Sophia M. Letcher, Jing Tang, Shuhong Jiang, Christian D. Gauthier, Sebastian R. Silveira, Caitlin M. Schroeder, Eleonora M. Lad, Alan D. Proia, Rudolph E. Tanzi, David M. Holtzman, Susanne Krasemann, Dong Feng Chen, Oleg Butovsky
Immunity. 2022-09-01
10.1016/j.immuni.2022.07.014

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
Laura M. Cox, Narghes Calcagno, Christian Gauthier, Charlotte Madore, Oleg Butovsky, Howard L. Weiner
Microbiome. 2022-03-11
10.1186/s40168-022-01232-z

Editorial: Role of Neuroinflammation in the Neuropsychiatric and Neurological Aspects of COVID-19
Marie-Eve Tremblay, Charlotte Madore, Li Tian, Alexei Verkhratsky
Front. Cell. Neurosci.. 2022-02-09
10.3389/fncel.2022.840121

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
Chao Wang, Monica Xiong, Maud Gratuze, Xin Bao, Yang Shi, Prabhakar Sairam Andhey, Melissa Manis, Caitlin Schroeder, Zhuoran Yin, Charlotte Madore, Oleg Butovsky, Maxim Artyomov, Jason D. Ulrich, David M. Holtzman
Neuron. 2021-05-01
10.1016/j.neuron.2021.03.024

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé
Nat Commun. 2020-11-30
10.1038/s41467-020-19861-z

Neuropathobiology of COVID-19: The Role for Glia
Marie-Eve Tremblay, Charlotte Madore, Maude Bordeleau, Li Tian, Alexei Verkhratsky
Front. Cell. Neurosci.. 2020-11-11
10.3389/fncel.2020.592214

CSF1R signaling is a regulator of pathogenesis in progressive MS.
Nellwyn Hagan, John L. Kane, Deepak Grover, Lisa Woodworth, Charlotte Madore, Jacqueline Saleh, Jose Sancho, Jinyu Liu, Yi Li, Jonathan Proto, Matija Zelic, Amy Mahan, Michael Kothe, Andrew A. Scholte, Maria Fitzgerald, Barbara Gisevius, Aiden Haghikia, Oleg Butovsky, Dimitry Ofengeim
Cell Death Dis. 2020-10-01
10.1038/s41419-020-03084-7

Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.
Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K. Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W. Dickson
acta neuropathol commun. 2020-06-24
10.1186/s40478-020-00970-1

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.
Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K. Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W. Dickson
acta neuropathol commun. 2020-05-19
10.1186/s40478-020-00947-0

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, Maya E. Woodbury, Alicia A. Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B. Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W. Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu
Mol Psychiatry. 2020-02-18
10.1038/s41380-020-0671-2

Microglia, Lifestyle Stress, and Neurodegeneration.
Charlotte Madore, Zhuoran Yin, Jeffrey Leibowitz, Oleg Butovsky
Immunity. 2020-02-01
10.1016/j.immuni.2019.12.003

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio‐Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl‐Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haass
EMBO Mol Med. 2019-05-23
10.15252/emmm.201809711

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.
Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel, Susanne Krasemann
acta neuropathol commun. 2019-05-22
10.1186/s40478-019-0735-1

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre
Brain, Behavior, and Immunity. 2019-02-01
10.1016/j.bbi.2018.07.025

TREMendous 2 Be Social.
Narghes Calcagno, Caroline Baufeld, Charlotte Madore, Oleg Butovsky
Immunity. 2018-05-01
10.1016/j.immuni.2018.04.034

Microglial Phenotypes and Functions in Multiple Sclerosis.
Elaine O’Loughlin, Charlotte Madore, Hans Lassmann, Oleg Butovsky
Cold Spring Harb Perspect Med. 2018-02-01
10.1101/cshperspect.a028993

Differential contribution of microglia and monocytes in neurodegenerative diseases.
Caroline Baufeld, Elaine O’Loughlin, Narghes Calcagno, Charlotte Madore, Oleg Butovsky
J Neural Transm. 2017-10-23
10.1007/s00702-017-1795-7

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott T. Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D. Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L. Heppner, Vladimir Litvak, David M. Holtzman, Hans Lassmann, Howard L. Weiner, Jordi Ochando, Christian Haass, Oleg Butovsky
Immunity. 2017-09-01
10.1016/j.immuni.2017.08.008

Early-life PUFAs modulate shaping of neuronal circuits by microglia

Glia. 2017-06-01
10.1002/glia.23157

Microglial confetti party.
Charlotte Madore, Caroline Baufeld, Oleg Butovsky
Nat Neurosci. 2017-05-25
10.1038/nn.4570

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass
EMBO Rep. 2017-05-08
10.15252/embr.201743922

Microglial biology and physiology
Oleg Butovsky, Charlotte Madore, Howard Weiner
Neuroimmune Pharmacology. 2016-12-23
10.1007/978-3-319-44022-4_13

The brain parenchyma has a type I interferon response that can limit virus spread.
Eugene Drokhlyansky, Didem Göz Aytürk, Timothy K. Soh, Ryan Chrenek, Elaine O’Loughlin, Charlotte Madore, Oleg Butovsky, Constance L. Cepko
Proc Natl Acad Sci USA. 2016-12-15
10.1073/pnas.1618157114

Activation of microglia by retroviral infection correlates with transient clearance of prions from the brain but does not change incubation time.
Christiane Muth, Katharina Schröck, Charlotte Madore, Kristin Hartmann, Zain Fanek, Oleg Butovsky, Markus Glatzel, Susanne Krasemann
Brain Pathology. 2016-11-21
10.1111/bpa.12441

Early life stress perturbs the maturation of microglia in the developing hippocampus.
Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffman
Brain, Behavior, and Immunity. 2016-10-01
10.1016/j.bbi.2016.06.006

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé
Neural Plasticity. 2016-01-01
10.1155/2016/3597209

Microglia in neuronal plasticity: Influence of stress
Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé
Neuropharmacology. 2015-09-01
10.1016/j.neuropharm.2014.12.034

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
Sophie Layé, Charlotte Madore, Isabelle St-Amour, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar, Frédéric Calon
NUA.
10.3233/nua-150049

Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agnès Aubert, Corinne Joffre, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2015-05-07
10.1038/npp.2015.127

Dysregulation of the homeostatic microglia signature in germ-free mice
Charlotte Madore, Zain Fanek, David Greco, Olga Kinner, Vladimir Yeliseyev, Lynn Bry, Oleg Butovsky
Journal of Neuroimmunology. 2014-10-01
10.1016/j.jneuroim.2014.08.433

Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
Charlotte Madore, Agnès Nadjar, Jean-Christophe Delpech, A. Sere, A. Aubert, Céline Portal, Corinne Joffre, Sophie Layé
Brain, Behavior, and Immunity. 2014-10-01
10.1016/j.bbi.2014.03.021

Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé
Neuropsychopharmacol. 2014-08-05
10.1038/npp.2014.196

N-3 polyunsaturated fatty acid and neuroinflammation in aging: Role in cognition
Sophie Layé, Charlotte Madore, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar
Pharma-Nutrition. 2014-01-01
10.1007/978-3-319-06151-1_6

Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide
C. Madore, C. Joffre, J.C. Delpech, V. De Smedt-Peyrusse, A. Aubert, L. Coste, S. Layé, A. Nadjar
Brain, Behavior, and Immunity. 2013-11-01
10.1016/j.bbi.2013.08.008

N-3 polyunsaturated fatty acids protect against the cognitive effects of a peripheral inflammation by targeting microglia morphofunctional activity

Glia. 2013-06-14
10.1002/glia.22530

Dietary lipids and microglia priming

Glia. 2013-06-14
10.1002/glia.22531

Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice
Thomas Larrieu, Charlotte Madore, Corinne Joffre, Sophie Layé
J Physiol Biochem. 2012-06-16
10.1007/s13105-012-0179-6

Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
Sophie Layé, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Corinne Joffre, Thomas Larrieu, Charlotte Madore, Agnès Nadjar and Lucile Capuron
OCL. 2011-11-15
10.1684/ocl.2011.0412