{"id":639,"date":"2025-09-01T17:27:45","date_gmt":"2025-09-01T15:27:45","guid":{"rendered":"https:\/\/nutrineuro.bordeaux.inrae.fr\/?post_type=buni_events&p=639"},"modified":"2025-09-01T17:27:46","modified_gmt":"2025-09-01T15:27:46","slug":"thesis-defense-lola-hardt","status":"publish","type":"buni_events","link":"https:\/\/nutrineuro.bordeaux.inrae.fr\/en\/events\/thesis-defense-lola-hardt\/","title":{"rendered":"Thesis defense – <\/span>Lola Hardt"},"content":{"rendered":"

Venue: Centre Broca<\/strong><\/p>\n

Defense in english<\/p>\n

\n

Title<\/h3>\n

Implication of polyunsaturated fatty acid (PUFA) biostatus in dopamine transmission-related reward processing deficits<\/em><\/p>\n

R\u00e9sum\u00e9<\/h3>\n

Reward processing deficits underly shared symptomatic dimension across psychiatric disorders such as schizophrenia, bipolar disorder and major depression. These impairments are often linked to dysfunction of mesocorticolimbic dopaminergic pathway, suggesting shared underlying mechanisms. Interestingly, clinical studies have consistently described a decrease in n-3 polyunsaturated fatty acids (PUFA) in a subpopulation of patients with these disorders (Conklin et al., 2010; Messamore and McNamara, 2016). Here we show that developmental n-3 PUFA deficiency leads to an imbalance in the mesocorticolimbic pathway with cortical hypodopaminergia and striatal hyperdopaminergia, together with aberrant wiring of striatal dopamine terminals\u00a0which relate to changes in gene networks involved in\u00a0neuronal transmission and\u00a0axon development in VTA DA neurons. Furthermore,\u00a0DA dynamics in relation with action reinforcement and reward prediction in the mPFC and the NAc, respectively, were found to be altered under n-3 PUFA deficiency, potentially revealing reward processing deficits implicated in related impaired behaviors. Indeed, n-3 PUFA deficiency while sparing\u00a0learning and flexible expression of action-outcome associations, leads to motivational deficits and increased choice impulsivity. Importantly, transgenic normalization of PUFA biostatus in DA neurons specifically was sufficient to prevent behavioral deficits, demonstrating the causal link between developmental n-3 PUFA deficiency, mesocorticolimbic imbalance and reward processing deficits, relevant to psychiatric disorders. By elucidating\u00a0\u00a0shared pathological mechanisms across diagnostic boundaries, this work might unravel neurodevelopmental and circuit level vulnerabilities under n-3 PUFA deficiency which could pave the way for early interventions, preventive strategies, and more personalized approaches to treatment in psychiatry with PUFA biostatus as a clinically relevant biomarker.<\/p>\n

Keywords:<\/strong>\u00a0Psychiatric Disorders, n-3 PUFA Deficiency, Reward Processing Deficits, Dopamine<\/strong><\/p>\n

 <\/p>\n

Publications<\/h3>\n

Roman Walle, Anna Petitbon, Giulia R. Fois, Christophe Varin, Enrica Montalban, Lola Hardt,<\/b> Andrea Contini, Maria Florencia Angelo, Myl\u00e8ne Potier, Rodrigue Ortole, Asma Oummadi, V\u00e9ronique De Smedt-Peyrusse, Roger A Adan, Bruno Giros, Francis Chaouloff, Guillaume Ferreira, Alban de Kerchove d\u2019Exaerde, Fabien Ducrocq, Fran\u00e7ois Georges, Pierre Trifilieff.
\n<\/i>Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure<\/i><\/b> (2023)
\ndoi: https:\/\/doi.org\/10.1101\/2022.05.05.490599<\/a><\/span><\/span><\/p>\n

Alessia Costa, Eva Ducourneau, Lorenzo Curti, Alessio Masi, Guido Mannaioni, Lola Hardt<\/b>, Essi F Biyong, Myl\u00e8ne Potier, Patrizio Blandina, Pierre Trifilieff, Gustavo Provensi, Guillaume Ferreira, M Beatrice Passani
\nChemogenetic activation or inhibition of histaminergic neurons bidirectionally modulates recognition memory formation and retrieval in male and female mice <\/b>(2023)
\ndoi: https:\/\/doi.org\/10.21203\/rs.3.rs-3714805\/v1<\/a><\/span><\/span><\/p>\n

Jury<\/h3>\n

Dr\u00a0<\/strong>BELUJON Pauline<\/strong>, Ma\u00eetresse de conf\u00e9rences, Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques, Rapporteure
\nDr GEORGES Fran\u00e7ois<\/strong>,\u00a0Directeur de recherche, Insitut de Maladies Neurod\u00e9g\u00e9n\u00e9rative,\u00a0CNRS UMR 5293, Invit\u00e9
\nDr TRIFILIEFF Pierre,\u00a0<\/strong>Directeur de recherche, Laboratoire NutriNeurO, UMR INRAE 1286, Directeur de Th\u00e8se
\nDr\u00a0<\/strong>CARNICELLA S\u00e9bastien<\/strong>, Directeur de recherche, Grenoble Institut des Neurosciences, Inserm U1216, Universit\u00e9 Grenoble Alpes, Rapporteur
\nDr\u00a0<\/strong>VALJENT Emmanuel,<\/strong>\u00a0Directeur de recherche, Institute For Neurosciences Of Montpellier, Examinateur
\nDr FLORES Cecilia<\/strong>, Full professor, The Douglas Research Centre, Examinatrice<\/p>\n","protected":false},"excerpt":{"rendered":"

Implication of polyunsaturated fatty acid (PUFA) biostatus in dopamine transmission-related reward processing deficits \/\/ Lieu : centre Broca<\/p>\n","protected":false},"template":"","categories":[],"class_list":["post-639","buni_events","type-buni_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nutrineuro.bordeaux.inrae.fr\/en\/wp-json\/wp\/v2\/buni_events\/639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nutrineuro.bordeaux.inrae.fr\/en\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/nutrineuro.bordeaux.inrae.fr\/en\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/nutrineuro.bordeaux.inrae.fr\/en\/wp-json\/wp\/v2\/media?parent=639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nutrineuro.bordeaux.inrae.fr\/en\/wp-json\/wp\/v2\/categories?post=639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}